A Good Glue Clamp

Gluing Together Software Components How Good is Your Glue

We have investigated an assessment technique for studying the failure tolerance of large scale component based information systems Our technique assesses the propagation of information through the interfaces between objects in order to predict how software will behave when cor rupt information gets passed Our approach is applicable to both source code and executable commercial o the shelf COTS ...

How a DNA polymerase clamp loader opens a sliding clamp.

Processive chromosomal replication relies on sliding DNA clamps, which are loaded onto DNA by pentameric clamp loader complexes belonging to the AAA+ family of adenosine triphosphatases (ATPases). We present structures for the ATP-bound state of the clamp loader complex from bacteriophage T4, bound to an open clamp and primer-template DNA. The clamp loader traps a spiral conformation of the ope...

Fibrin Glue in Postlaryngectomy Fistula-A Case Report

Introduction: One of the most common complications following total laryngectomy is pharyngocutaneous fistula (PCF). Various methods have been proposed to treat this disorder in recent studies, including a range of simple and conservative treatments to more aggressive therapies, such as various surgical procedures. One of the most innovative and least developed methods is the use of plasma...

A New Eyelid Clamp

NCAM and Vesicle Cycling The Importance of Good Glue in the Long Run

Careful functional dissection of mouse neuromuscular junctions (NMJs) formed in the absence of NCAM reveal that in spite of relatively normal morphology and ultrastructure, the presynaptic terminals have profound alterations in the mechanisms of recycling of synaptic vesicles. These alterations, including the appearance of a brefeldin-sensitive pathway, leave synaptic transmission impaired for ...